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Stomach & Duodenum

Stomach & Duodenum

Stomach

The stomach is a J-shaped muscular pouch that is situated in the upper left part of the abdominal cavity behind the lower ribs. It connects to the esophagus above and the duodenum below. The primary function of the stomach is to receive the food and break it down.

Duodenum

The first part of the small intestine is called the duodenum. This C-shaped structure is 10 inches long and also the shortest and widest part of the small intestine. Bile and pancreatic duct open into the second portion of the duodenum. Once the partially digested food enters from the stomach, it mixes with digestive juice and the digestion process continues. The enzymes in the duodenum are responsible for the digestion of protein, fats, and carbohydrates found in the chyme before it advances into the small intestines.

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Gastritis

Gastritis is the inflammation of the protective mucus lining of the stomach. When the stomach lining is weak, thin or damaged, digestive juices damage it causing gastritis. While acute gastritis occurs due to sudden and severe inflammation.

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Stomach cancer

Gastric cancer is the third most common cause of cancer-related deaths globally. Stomach Cancer often grows slowly over the years and is usually left unnoticed at the onset of the disease.

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Gastric lymphoma

Lymphoma is a type of cancer that affects the lymphoid tissue at the stomach wall, which forms a part of the immune system. Lymphoma of the stomach is known as gastric lymphoma. About 5% of the cancers found in the stomach are usually attributed to gastric lymphoma, making it the second most common cancer in the stomach after adenocarcinoma. Those aged over 50 years are known to be affected by gastric lymphoma the most, with males posing a greater risk of developing them. Helicobacter Pylori infection is one of the etiologies. Chemotherapy is the mainstay of treatment. Antibiotics for H.Pylori eradication is also required in positive cases.

Gastrointestinal Stromal Tumor (GIST)

Gastrointestinal stromal tumors (GISTs) are thought to grow and develop from certain specialized cells found specifically in the gastrointestinal tract. These cells are called interstitial cells of Cajal (ICCs). Though GISTs can start from anywhere in the GI tract, more than half of them start from the stomach. GISTs were also found to spread and grow in other parts of the body and they are classified based on its size, where it’s located and how fast they divide. GISTs are often asymptomatic. Rare symptoms are bloody stools, abdominal pain and feeling full after small meals. Surgery is the best solution for those suffering from GISTs as it is the best chance of a cure. After surgery adjuvant therapy may be employed to treat patients who might have a high risk of tumor recurrence. Imatinib and Sunitinib are the two most common drugs used to treat GISTs by adjuvant therapy. Sometimes they present with very large size tumor. In such cases, Imatinib started first to reduce the size followed by surgery performed.

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